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Adrenotone Plus™

  • ADAPTOGENIC HERBAL SUPPORT
  • NUTRITIONAL ADRENAL REJUVENATION
  • CATECHOLAMINE REPLENISHMENT
  • STRESS NUTRIENT REPLACEMENT
 

Adrenotone Plus is a formulary, encapsulated product designed to be an all-in-one adrenal support product. In just one product it is now possible for the clinician to provide botanical and nutritional enhancement of adrenal cortical and medullary function, adrenal rejuvenation, increased hypothalamic receptor function, and address depletions common to those suffering from the effects of chronic stress.

SPECIFIC CLINICAL OBJECTIVES OF ADRENOTONE PLUS:

Adaptogenic and adrenal tonic herbs and nutrients have been included in order to help the body's adaptation to stress and to support adrenal gland health. Stress can alter levels of cortisol and catecholamines, in addition to causing the depletion of a host of micronutrients. Cortisol increases have vast effects over serum blood glucose and insulin levels, inducing dysglycemia and laying the foundation for metabolic syndrome.

Adrenotone Plus contains a blend of standardized botanicals including: Eleuthrococcus (Siberian ginseng),
Panex quinquefolius (American ginseng- strong, yet least stimulating of the ginsengs), Ashwagandha (Indian ginseng or Withania), Rhodiola rosea (Rose root), and Glcyrrhiza glabra (Licorice root), all known to be tonifying and rejuvenating to the adrenal gland. The ginseng family of herbs possesses a unique property of aiding in the regeneration and enhanced function of hypothalamic cortisol receptors, providing an amphoteric effect, which allows the body to better self-regulate cortisol levels. Licorice potentiates and extends the serum life of cortisol, thereby lessening the demand on the adrenal cortex during stressful conditions. N-Acetyl-tyrosine, the most bioavailable form of tyrosine, is included as a critical building block of catecholamines, which are often depleted under chronic stress conditions, various neurotransmitters, and thyroid hormones. Also included are the nutrients: vitamin C, pantothenic acid (B5), pyridoxine-B6 (as P-5- P), riboflavin-B2 (as R-5-P), and folic acid, which play critical roles as enzyme co-factors in the balanced production of stress hormones. All of these ingredients are combined in order to synergistically promote proper homeostasis of serum cortisol, helping to promote healthy hypothalamic-pituitary function, aid in the production and replenishment of depleted catecholamines, support adrenal cortical health, and to
replete common nutritional deficiencies that can result from chronic stress.
 
 
 
 

*Safety Alert:

Ingestion of greater than 3 g/day of licorice root or 100 mg/day of glycyrrhizin for more than six weeks can cause water retention, hypertension, hypokalemia, and suppression of the renin-angiotensin system. Monitoring of blood pressure and electrolytes and increasing daily potassium intake is suggested if using dosages referred to in this alert statement. Licorice containing products should be used with caution and under supervision in those with preexisting hypertension, renal disease, or those taking digitalis preparations.

References:

1. Farnsworth NR, Kinghorn AD, Soejarto D, Walker DR. Siberian ginseng (Eleutherococcus senticosus). Current status as an adaptogen. Econ Med Plant Res 1985; 1: 156-215

2. Branov AI. Medicinal uses of ginseng and related plants in the Soviet Union. Recent trends in the Soviet Union. Recent trends in the Soviet literature. J Ethnopharmacol 1982; 6: 339-353

3. Brekhman II, Dardymov IV. Pharmacological investigation of glycosides from ginseng and Eleutherococcus. Lloydia 1969; 32: 46-51

4. Brekhman II, Kirillov OI. Effect of Eleutherococcus and alarm phase of stress. 1969; 8: 113-121

5. Asano K et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med 1986; 53: 175-7

6. Chen SE, Sawchuk RJ, Staba EJ. American ginseng III. Pharmacokinetics of ginsenosides in the rabbit. Eur J of Drug Metab Pharmacokin 1980; 5(3): 161-8

7. Yuan CS et al. Modulation of American ginseng on brain stem GABA-ergic effects in rats. J of Ethnopharmacol 1998; 62(3): 215-22.

8. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J of Ethnopharmacol 1999; 64(1): 91-3

9. Dhuley JN. Adaptogenic and cardioprotective action of ashwaganda in rats and frogs. J of Ethnopharmacol 2000; 70(1): 57-64.

10. Standeven R. Withania somnifera. Eur J Herbal Med 1998; 4(2): 17-22

11. Kelly GS. Rhodiola rosea: A possible plant adaptogen. Altern Med Rev 2001; 6(3): 293-302

12. Tolonen A, Pakonen M, Hohtola A, Jalonen J. Phenylpropanoid Glycosides from Rhodiola rosea. Chem Pharm Bull (Tokyo). 2003; 51(4): 467-70.

13. Underwood A. Herbal stress buster? Newsweek. 2003; Feb 3; 141(5): 63-4

14. Rhodiola rosea. Monograph. Altern Med Rev. 2002; 7(5): 421-3

15. MacKenzie MA, Jansen RW, Hoefnagels WH et al. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab 1990; 70:

1637-1643

16. Chen MF, Shimada F, Kato H et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Japan 1990; 37: 331-341

17. Teelucksingh S, Mackie AD, Burt D et al. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990; 335: 1060-1063

18. Takeda R, Morimoto S, Uchida K et al. Prolonged pseudoaldosteronism induced by glycyrrhizin. Endocrinol Japan 1979; 26: 541-547

19. Epstein M, Espiner E, Donals R et al. Effect of eating licorice on the renin-angiotensin aldosterone axis in normal subjects. Br Med J 1977; 1: 488-90.

20. Groff JL, Gropper SS. Advanced Human Nutrition and Human Metabolism (3rd ed.). Belmont, CA: Wadsworth: 2000

21. Shils ME et al. Modern Nutrition in Health and Disease (9th ed.). Baltimore, MD: Lippincott Williams & Wilkins: 1999

22. Marz RB. Medical Nutrition from Marz (2nd ed.). Portland, OR: Omni Press: 1999.

23. Fry PC et al. Metabolic response to a pantothenic acid deficient diet in humans. J Nutr Sci Vitaminol 1976; 22: 339-346

24. Baily LB. Folate in Health and Disease. New York: Marcel Dekker: 1995

25. Driskell JA. Vitamin B6 requirements of humans. Nutr Res 1994; 14: 293-324

26. Middleton HM. Intestinal absorption of pyridoxyl-5-phosphate, Disappearance from perfused segments of rat jejunum in vivo. J Nutr 1979; 109: 975-981

27. Levine M. New concepts in the biology and biochemistry of ascorbic acid. New Engl J Med 1986; 314: 892-902

THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS.THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARY SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION.

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