Adrenotone Plus contains a blend of standardized botanicals including: Eleuthrococcus (Siberian ginseng),
Panex quinquefolius (American ginseng- strong, yet least stimulating of the ginsengs), Ashwagandha (Indian ginseng or Withania), Rhodiola rosea (Rose root), and Glcyrrhiza glabra (Licorice root), all known to be tonifying and rejuvenating to the adrenal gland. The ginseng family of herbs possesses a unique property of aiding in the regeneration and enhanced function of hypothalamic cortisol receptors, providing an amphoteric effect, which allows the body to better self-regulate cortisol levels. Licorice potentiates and extends the serum life of cortisol, thereby lessening the demand on the adrenal cortex during stressful conditions. N-Acetyl-tyrosine, the most bioavailable form of tyrosine, is included as a critical building block of catecholamines, which are often depleted under chronic stress conditions, various neurotransmitters, and thyroid hormones. Also included are the nutrients: vitamin C, pantothenic acid (B5), pyridoxine-B6 (as P-5- P), riboflavin-B2 (as R-5-P), and folic acid, which play critical roles as enzyme co-factors in the balanced production of stress hormones. All of these ingredients are combined in order to synergistically promote proper homeostasis of serum cortisol, helping to promote healthy hypothalamic-pituitary function, aid in the production and replenishment of depleted catecholamines, support adrenal cortical health, and to
replete common nutritional deficiencies that can result from chronic stress.
References:
1. Farnsworth NR, Kinghorn AD, Soejarto D, Walker DR. Siberian ginseng (Eleutherococcus senticosus). Current status as an adaptogen. Econ Med Plant Res 1985; 1: 156-215
2. Branov AI. Medicinal uses of ginseng and related plants in the Soviet Union. Recent trends in the Soviet Union. Recent trends in the Soviet literature. J Ethnopharmacol 1982; 6: 339-353
3. Brekhman II, Dardymov IV. Pharmacological investigation of glycosides from ginseng and Eleutherococcus. Lloydia 1969; 32: 46-51
4. Brekhman II, Kirillov OI. Effect of Eleutherococcus and alarm phase of stress. 1969; 8: 113-121
5. Asano K et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med 1986; 53: 175-7
6. Chen SE, Sawchuk RJ, Staba EJ. American ginseng III. Pharmacokinetics of ginsenosides in the rabbit. Eur J of Drug Metab Pharmacokin 1980; 5(3): 161-8
7. Yuan CS et al. Modulation of American ginseng on brain stem GABA-ergic effects in rats. J of Ethnopharmacol 1998; 62(3): 215-22.
8. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J of Ethnopharmacol 1999; 64(1): 91-3
9. Dhuley JN. Adaptogenic and cardioprotective action of ashwaganda in rats and frogs. J of Ethnopharmacol 2000; 70(1): 57-64.
10. Standeven R. Withania somnifera. Eur J Herbal Med 1998; 4(2): 17-22
11. Kelly GS. Rhodiola rosea: A possible plant adaptogen. Altern Med Rev 2001; 6(3): 293-302
12. Tolonen A, Pakonen M, Hohtola A, Jalonen J. Phenylpropanoid Glycosides from Rhodiola rosea. Chem Pharm Bull (Tokyo). 2003; 51(4): 467-70.
13. Underwood A. Herbal stress buster? Newsweek. 2003; Feb 3; 141(5): 63-4
14. Rhodiola rosea. Monograph. Altern Med Rev. 2002; 7(5): 421-3
15. MacKenzie MA, Jansen RW, Hoefnagels WH et al. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab 1990; 70:
1637-1643
16. Chen MF, Shimada F, Kato H et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Japan 1990; 37: 331-341
17. Teelucksingh S, Mackie AD, Burt D et al. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990; 335: 1060-1063
18. Takeda R, Morimoto S, Uchida K et al. Prolonged pseudoaldosteronism induced by glycyrrhizin. Endocrinol Japan 1979; 26: 541-547
19. Epstein M, Espiner E, Donals R et al. Effect of eating licorice on the renin-angiotensin aldosterone axis in normal subjects. Br Med J 1977; 1: 488-90.
20. Groff JL, Gropper SS. Advanced Human Nutrition and Human Metabolism (3rd ed.). Belmont, CA: Wadsworth: 2000
21. Shils ME et al. Modern Nutrition in Health and Disease (9th ed.). Baltimore, MD: Lippincott Williams & Wilkins: 1999
22. Marz RB. Medical Nutrition from Marz (2nd ed.). Portland, OR: Omni Press: 1999.
23. Fry PC et al. Metabolic response to a pantothenic acid deficient diet in humans. J Nutr Sci Vitaminol 1976; 22: 339-346
24. Baily LB. Folate in Health and Disease. New York: Marcel Dekker: 1995
25. Driskell JA. Vitamin B6 requirements of humans. Nutr Res 1994; 14: 293-324
26. Middleton HM. Intestinal absorption of pyridoxyl-5-phosphate, Disappearance from perfused segments of rat jejunum in vivo. J Nutr 1979; 109: 975-981
27. Levine M. New concepts in the biology and biochemistry of ascorbic acid. New Engl J Med 1986; 314: 892-902