PROBIOTIC

SYNERGY

By:By: Linda Lizotte, R.D. and Cristiana Paul, M.S.

• Immune defense at the intestinal and systemic level
• Minimize the side effects of antibiotics
• Minimize allergic responses
• Prevention/alleviation of traveler's diarrhea
• Prevention/alleviation of diarrhea and constipation in infants, adults and elderly
• Inhibit growth of pathogenic organisms: bacteria, yeast,parasites
• Improve digestion of lactose
• Alleviate inflammatory bowel disease/ulcerative colitis
• Vitamin K synthesis
• Alleviate atopic dermatitis

Designs for Health reformulated Probiotic Synergy because of new research and new patented delivery technology. You will find four new strains in this formula as compared to the old Probiotic Synergy capsule. We became impressed with these strains after reading the research on them. You can find short summaries of these studies on page 2. This unique delivery technology is designed to ensure that the bacteria survive passage through the stomach to the small intestine. The delivery system involves gel-forming polysaccharides that are insoluble at a low (acidic) pH like that in the stomach. When this capsule enters the stomach, it begins to dissolve in the gastric juice. The polysaccharides in the gel rehydrate and form an insoluble gel matrix. The protected bacteria move their way to the small intestine where the increased, more alkaline pH causes the probiotics to release - right where we want them.

This Newly Improved Probiotic formula has a two year shelf life at room temperature but refrigeration is highly recommended. There is now no need to overstuff the capsules to account for die-off of organisms due to their typical instability to stomach acid. These new capsules contain about 4 billion live active healthy bacteria.

Contents:

One DFH Probiotic Synergy capsule contains:

1.68 billion Lactobacillus

Acidophilus LA-5, 1.68 billion Bifidobacterium BB-12, .44 billion Streptococcus

thermophilus, and .20 billion Lactobacillus delbruekii ssp bulgaricus.

Recommended Use:

3 capsules per day with food, if possible, since this unique capsule technology works better with food in the stomach. Take at least 3 hours away from administration of antibiotics.

Some factors that increase the need for probiotics are:

• Infants being delivered by C-section or that are not breast fed long enough to establish a strong friendly flora as an important foundation for their immunological health

• Pasteurization of foods and decreased consumption of fermented foods

• Increase in the use of antibiotics in our livestock

• Overuse of antibiotics in treating human infections which may not be caused by bacteria

• Over consumption of sugar and carbohydrates which promote yeast overgrowth

• Over consumption of alcohol which promotes yeast overgrowth

Summary:

1) Advanced technology capsule forms a gel matrix to protect from stomach acid

2) Probiotic Synergy is stored and shipped cold to prevent overheating, which can lower viability.

3) It is also stored and shipped to you in a glass bottle, with two high-tech dessicant packets, providing even more protection

and stability to these live probiotics.

4) Four strain formula, including the Bifidobacterium BB-12 and Lactobacillus Acidophilus LA-5, backed by human research

Research Summary:

Four healthy adults received 1 Probiotic capsule at each meal (acid resistant capsule- 4 billion count per cap). Both strains were found in the duodenum after ingestion indicating survival through the stomach. The number of bifidobacteria in the feces increased significantly during treatment indicating adherence and colonization. This is an indication that the strains are surviving when taken with food.) This small but promising study shows a need for further research on this subject.

When LA-5 (Lactobacillus acidophilus), BB-12 (Bifidobacterium), Streptococcus thermophilus and Lactobacillus bulgaricus were given (3.5 billion, twice a day) to 23 healthy subjects receiving an antibiotic 4 times daily for 7 days, the total number of healthy microorganisms was significantly higher in the group receiving the probiotics, and only 18% of the probiotic group was colonized with clostridium dificile compared to 41% of the placebo group. C. dificile is a cause of diarrhea.

When 23 geriatric patients were given fermented milk that contained .4-1.6 billion Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 strains, there was a significant improvement in frequency of bowel movements and diminished need for laxatives that have a negative effect on electrolyte balance.

Phagocytic activity of leukocytes and phagocytosis of E. Coli were both enhanced after administration of BB-12 fermented milk to 28 healthy adults for three weeks.

When 30 healthy adults were given fermented milk that contained BB-12 and Lactobacillus Acidophilus, and then given Salmonella typhi to mimic an enteropathogenic infection, the number of fecal bacteria increased. Serum IgA titre to Salmonella typhi was significantly higher (four fold), total serum IgA significantly increased and IgG titres remained higher longer than the control group.

.

54 infants in a double-blind randomized controlled trial were breast fed or fed a fermented milk formula containing Streptococcus thermophilus and BB-12. The formula with these strains induced bifidobacterium colonization at 1 month of age.The BB-12 formula was well tolerated and promoted normal growth in the infants.

Clinical symptoms of atopic dermatitis improved significantly after supplementation of BB-12 Bifidobacterium to patients on an elimination diet compared to those on the diet that received placebo.

A double-blind study was performed on 16 patients with proctocolectomy for ulcerative colitis. Those given LA-5 and BB-12 strains decreased daily stools from 5.8 to 2.8 and the number of LA-5 and BB-12 in the stools increased significantly

.

Protection rate against traveler's diarrhea was 39% in 94 healthy tourists.

References available electronically upon request.

THIS SCIENTIFIC INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS

AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS

INFORMATION IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH

CARE PROVIDERS TO USE AS A SCIENTIFIC BASIS FOR DETERMINING WHETHER

TO RECOMMEND PARTICULAR PRODUCTS TO THEIR PATIENTS. THIS

MEDICAL INFORMATION IS NOT PROVIDED OR INTENDED FOR USE BY

CONSUMERS. THESE PRODUCTS ARE DIETARY SUPPLEMENTS, NOT DRUGS, NOR

ARE THEY OFFERED AS ALTERNATIVES OR ADJUNCTS TO DRUGS. THESE

SUPPLEMENTS ARE FOR NUTRITIONAL SUPPORT ONLY AND ARE NOT INTENDED

FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR

MITIGATE ANY DISEASE OR DISEASE CONDITION.